First-in-class approach to pin down tumor exosomes

Exploiting two Cancer Hallmarks: Tumor Metabolism and Genomic Instability.

IMAGINE A WORLD IN WHICH CANCER DIAGNOSIS IS POSSIBLE FROM A

 SIMPLE BLOOD DRAW

Cancer is a heterogeneous and complex disease, comprising over 200 diseases characterized by abnormal cell growth. Some fundamental processes arise as common hallmarks of all cancers and can provide unifying elements for disease detection.

Reprogramming of cancer cell metabolism: altered metabolism is key for cancer development, sustaining the high rate of proliferation of cancer cells.  Exosomics Siena has dedicated extensive efforts to identify the so called “Warburgian” markers  so they can be exploited in liquid biopsy settings.

The revolutionary solution came from the detection of this category of markers on circulating exosomes, enabling selective isolation of  of tumor-derived vesicles.

Exosomes are membranous nanovesicles released from all living cells in a finely regulated way and reflecting the cell-of-origin function and status. These tiny lipidic vesicles are true surrogates of a parent cell: they carry specific payload of molecules (proteins, lipids, nucleic acids etc.). Selective isolation and analysis of circulating tumor originated exosomes provide a true noninvasive tumor tissue biopsy yielding real-time information on tumor occurrence and progression, as well on tumor phenotype.

CANCER SCREENING: BEST PROTECTION IS EARLY DETECTION

Most cancers could be cured if detected at an early enough stage

Current cancer diagnostics is invariably invasive, not-conclusive and multi-step process, with associated high costs and considerable patients discomfort. Screening tests are today available for only a few solid tumors and most of the tumors are not detected at an early stage due to the lack of appropriate tools and biomarkers.

Exosomics provides revolutionary solution for solid tumors screening

  • One test fits all tumors
  • Non-invasive – blood based
  • Low interval, low cost
  • High accuracy

PRECISION MEDICINE STARTS WITH PRECISION DIAGNOSTICS

BETTER UNDERSTANDING – BETTER TREATMENT

We have developed a unique, patented methodology to isolate tumor derived vesicles and harvest the information contained within their DNA and RNA, as well as in associated cell-free circulating DNA from blood.

We use a spectrum of affinity isolation tools that can provide us ever more selective enrichment of clinically relevant targets from the sample enabling true tumor biopsy from blood.

This is the basis of our seleCTEV and soRT-EV assay families for analysis of DNA alterations (point mutations, insertions, deletions) and RNA isoforms (splicing variants, gene fusions, gene amplifications) implicated in prognosis and selection of the right treatment for the oncological patients.